Louise of Savoy was a daughter of
Filippo II the Landless, who was Duke of Savoy from 1496-97.
At the age of 12 she married Charles d'Orléans, Count of Angoulême in 1488. After the early death of her husband (1496), she dedicated herself to bringing up her children Marguerite (*1492) and François (*1494) in the spirit of the Renaissance. She realized the chance of
François for the throne of France and ensured good relations with
King Louis XII.
After the death of Louis' wife
Anne de Bretagne, Louise succeeded in making François the son-in-law of the king: Louis XII appointed François heir to the throne after his marriage to his daughter Claude, heiress to Brittany.
Louise was skilled and experienced in dealing with politically tricky situations. François made her regent twice, in 1515 on the occasion of his first campaign in Italy and in 1525-1526, when he was captured by the emperor. In an effort to free him, Louise established political connections with London and Constantinople. Eventually, the king was released in exchange for his sons François and
Henri. Louise negotiated the so-called women's peace of Cambrai with
Margaret of Austria in 1529, which ended the 2nd war between her son François I and Emperor Charles V.